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Cannabidiol News March 8 2019

Posted On March 8, 2019 at 6:37 am by / No Comments

 
 
zynerba logo
Zynerba up 17% premarket on new cannabidiol gel patent
Feb. 26, 2019 8:00 AM ET|About: Zynerba Pharmaceuticals (ZYNE)|By: , SA News Editor

The USPTO has issued a new patent, No. 10,213,390, to Zynerba Pharmaceuticals (NASDAQ:ZYNE) covering the use of its cannabidiol transdermal gel (ZYN002) to treat Fragile X syndrome, an inherited disorder characterized by learning disabilities and cognitive impairment.  Shares are up 17% premarket on increased volume.

At Zynerba Pharmaceuticals, our team is dedicated to developing next-generation transdermally-delivered cannabinoid therapeutics for patients affected by rare and near-rare neuropsychiatric conditions. Often, these diseases have few, if any, treatment options and can leave patients and their families feeling helpless and alone. Zynerba is committed to developing breakthrough therapies to transform the quality of lives of patients and their families as they battle these conditions.


 
 

 

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CRXPF

GlobeNewswire
Based on Elite’s previous success in cultivating 120 acres of similarly situated land in August 2018, the estimated production of hemp from the MYM parcel of land is 120,000 pounds per harvest with a CBD level of 10%-19%. This represents potential revenue of over $26 million, of which MYM is entitled to 50% less processing and sales fees.

 

OCTOBER 8, 2014
Home
During hearings on marijuana law in the 1930’s, claims were made about marijuana’s ability to cause men of color to become violent and solicit sex from white women. This imagery became the backdrop for the Marijuana Tax Act of 1937 which effectively banned its use and sales.


hhs

 

Health and Human Services,   Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, Health and Human Services, 
 
This decision was based, in part, on the conclusion by the Department of Health and Human Services that marijuana has no “currently accepted medical use” and there are “no adequate and well-controlled studies proving efficacy.”
1963 CBD was isolated by Dr. Mechoulam… Israel
1964 THC was isolated. Dr. Mechoulam… Israel
2009. The Endocannabinoid System was discovered by… Dr. Mechoulam… Israel. 
1963 through present day… who in part funds this research in Israel? 
The United States Government. 
 
 



2018 Marijuana research funded by the United States Government hits 50 years. 

 

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The University of Mississippi 



 

Who funds the research? 

 

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50 years or research approved and funded by the United States Government
Who gives approval for orphan drug status allowing drugs to be tested and made?
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The FDA granted approval of Epidiolex to GW Research Ltd.

 

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What will their drug cost that is really CBD?
$32,000 per year.

 


 

2016

The Drug Enforcement Agency

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(DEA) announced in August 2016 that marijuana will remain a Schedule I drug which means that it has no currently accepted medical use in the United States, it lacks an accepted safety use under medical supervision and it has a high potential for abuse. This decision was based, in part, on the conclusion by the Department of Health and Human Services that marijuana has no “currently accepted medical use” and there are “no adequate and well-controlled studies proving efficacy.”

 
2003
United States Patent 6,630,507
Assignee: The United States of America as represented by the hhs Department of Health and Human Services (Washington, DC) 
Cannabinoids as antioxidants and neuroprotectants 
Scott Salisbury… what is a Cannabinoid? CBD is a cannabinoid. THC is a Cannabinoid. 
Scott Salisbury… what is Marijuana then? The Federal Government uses the term to express a Cannabis plant to have above .03% THC. Cannabis is the genre… Hemp and Marijuana are in fact Cannabis. 
Cannabis, Cannabinoids, The Endoccananobid system. Phytocannabinoids blah. 

2013 Scott Salisbury does a google search against 
Oxidative stress because of reading about antioxidants. And… 

Neurodegenerative diseases and oxidative stress

KJ Barnham, CL MastersAI Bush – Nature reviews Drug discovery, 2004 – nature.com
Oxidative stress has been implicated in the progression of Alzheimer’s disease, Parkinson’s
disease and amyotrophic lateral sclerosis. Oxygen is vital for life but is also potentially
dangerous, and a complex system of checks and balances exists for utilizing this essential 

March 8 2019… 
Does hemp contain CBD? No! It contains CBDA. How does one get CBD? One activates CBD by eliminating the A. 

AGRICULTURE IMPROVEMENT ACT OF 2018

Link to the entire transcript Agriculture Improvement Act of 2018

SEC. 297A. DEFINITIONS.

“In this subtitle: “(1) Hemp.–The term `hemp’ means the plant Cannabis sativa L. and any part of that plant, including the seeds thereof and all derivatives, extracts, cannabinoids, isomers, acids, salts, and salts of isomers, whether growing or not, with a delta- 9 tetrahydrocannabinol concentration of not more than 0.3 percent on a dry weight basis. “(2) Indian tribe.–The term `Indian tribe’ has the meaning given the term in section 4 of the Indian Self-Determination and Education Assistance Act (25 U.S.C. 5304).

SEC. 10114. INTERSTATE COMMERCE. (a) Rule of Construction.–Nothing in this title or an amendment made by this title prohibits the interstate commerce of hemp (as defined in section 297A of the Agricultural Marketing Act of 1946 (as added by section 10113)) or hemp products. (b) Transportation of Hemp and Hemp Products.–No State or Indian Tribe shall prohibit the transportation or shipment of hemp or hemp products produced in accordance with subtitle G of the Agricultural Marketing Act of 1946 (as added by section 10113) through the State or the territory of the Indian Tribe, as applicable.

The Hemp Farming Act provisions in the Agriculture Improvement Act of 2018 (2018 Farm Bill) signed into law on December 20, 2018:

·         Removed hemp and its derivatives from the list of controlled substances;

·         Established hemp as a legal agricultural commodity;

·         Authorized the production, consumption, and sale of hemp and hemp-derived products in the United States, consistent with other federal laws, like the Food, Drug and Cosmetic Act;

·         Authorized the use of federal funds to support hemp research under the National Agricultural Research, Extension National Agricultural Research, Extension, and Teaching Policy Act of 1977 and the Critical Agricultural Materials Act; and

·         Explicitly established the protection of the interstate commerce of hemp or hemp products and further prevented states and tribal governments from prohibiting the transportation of hemp or hemp products through the State or the territory of the Indian Tribe.

  • Section 297D(c)(p. 434): Nothing in the new law affects the FDA’s authority under the Food, Drug, and Cosmetic Act or the Public Health Service Act.

  • Section 12619 (p. 540): Hemp is removed from the definition of “marihuana,” and THC found in hemp is excluded from the definition of a controlled substance.

  • Section 297A (p. 429) Defines hemp as all parts of the plant less than 0.3% THC, including “derivatives,” “extracts” and “cannabinoids” and permits hemp production in all states and territories.

  • p. 739: “While states and Indian tribes may limit the production and sale of hemp and hemp products within their borders, the Managers, in Section 10122, agreed to not allow such states and Indian tribes to limit the transportation or shipment of hemp or hemp products through the state or Indian territory.


It’s easy to see why people are so excited about this crop. Consider that an acre of tobacco in Tennessee these days can fetch between five and 10 thousand dollars tops. An acre of hemp could bring up to 50-thousand dollars in the marketplace. 

Wyoming 

U.S. News & World Report

The Wyoming Tribune Eagle reports that Gordon signed House Bill 171 on Wednesday. The legislation sponsored by Republican Rep. Bunky Loucks, of Casper, allows for hemp to be grown in the state, along with the production and sale of hemp-based products, including ones containing CBD oil.

Stuart, U.S. attorney for the Southern District of West Virginia, argued the farmers broke from the specifics of their hemp permit application to the state Department of Agriculture, thus violating the federal Controlled Substances Act when they purchased their seeds in Kentucky, not internationally, as they had indicated on the application.
 
 
 
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